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The association of chronic myocardial infarction scar detected by DE-MRI with ventricular Remodeling in coronary artery disease

Purpose: The aim of this study was to investigate the relationship between myocardial infarction scar and ventricular Remodeling by Delayed-Enhancement Magnetic Resonance Imaging (DE-MRI).

Methods: From June 2009 to May 2013, 20 patients with coronary heart disease who didn’t have a history of acute onset in the last three months were admitted. All patients were diagnosed by DE-MRI. The data including Left Ventricular (LV) Systolic Wall Thickening (WT), Wall Thickening Rate (WTR), Wall Motion Score (WM) and Ejection Fraction (EF) were analysed by Argus software. The myocardial infarction scar score was analysed by DE-MRI according to segment number and transmural extent.

Results: The myocardial infarction scar scored by DE-MRI was negatively correlated with the WT, WTR and EF with a correlation coefficient (R) of -0.788, -0.756 and -0.804, respectively (P<0.05). The myocardial infarction scar scored by DE-MRI was strongly positively correlated with WM with a correlation coefficient (R) of 0.81 (P<0.05).

Conclusion: The myocardial infarction scar score by DE-MRI was negatively correlated with the WT, WTR and EF but scar burden by DE-MRI is strongly and positively correlates with Regional Wall Motion Abnormality (RWMA). Further studies with a larger number of samples are warranted.

Author(s): Xinxiang Zhao, Yanglin Zhang, Chengrong Pu, Lin Sun, Wei Zhang, Renhui Cai