Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Research Article - Biomedical Research (2017) Volume 28, Issue 7

Synthesis and anti-inflammatory activity in myocarditis of (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2.1] octane-2-carboxamide

The new heterocycles compound (2S, 5R)-6-(benzyloxy)-7-oxo-1, 6-diazabicyclo [3.2.1] octane-2- carboxamide, designed using (2S, 5R)-5-((benzyloxy) amino) piperidine-2-carboxylate oxalate as start material, was successfully obtained via multiple synthesis route and finally characterized by IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The title compound was then screened for the in vivo anti-inflammatory property utilizing a standard acute carrageenan-induced paw oedema method in rats, and the compound showed promising activity.

Author(s): Xiao-Hui Liu, Yan Liu, Yu Zheng

Abstract Full Text PDF

Get the App