One of the key biological materials that can be used for disease diagnosis is the blood. The first step to examine the blood is separation of molecules in blood. In this work, the meander structure based microfluidic channel with different dimensions is designed for filtering applications. The performance characteristic of microchannel is analysed for symmetric and asymmetric geometries. The geometrical parameters such as Reynolds number and friction factor is computed and plotted. The symmetric microchannel geometry with width 250 μm gives the better performance when compared to all other microfluidic channel geometries.