Asian Journal of Biomedical and Pharmaceutical Sciences

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Studies on Process Parameters for Production of Lovastatin

Lovastatin is a natural secondary metabolite produced by Aspergillus terreus. Optimization of different process parameters like pH of medium, incubation period and selection of different carbon sources etc. was investigated for maximum production of lovastatin using Aspergillus terreus NCIM 657. The kinetics of lovastatin production was also investigated up to fourteen days of production under batch mode. It was found that a temperature of 28 ?C for incubation, a medium pH 6.5 and an agitation speed of 180rpm for seven days yielded maximum concentration of lovastatin. It was also observed that glucose as a sole carbon source resulted in diminished production of lovastatin as compared to cases where other carbon sources were supplemented in medium along with glucose. Thin layer chromatography, Fourier Transform Infrared spectroscopy analysis confirmed the presence of lovastatin in the sample produced by A. terreus NCIM 657

Author(s): Riya Dhar and Vinod Kumar Nigam