Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2017) Volume 28, Issue 16

Role of ErbB3 binding protein 1 (EBP1) as a predictor in hepatocellular carcinoma

Background: The role of ErbB3 Binding Protein 1 (EBP1) in Hepatocellular Carcinoma (HCC) prognosis was inconsistent. Therefore, we performed this study to determine the effect of EBP1 in HCC prognosis.

Methods: 146 patients underwent resection of HCC were collected between 2010 and 2015. Overall Survival (OS) analysis was performed with Kaplan-Meier with log rank test. The prognostic value of EBP1 was evaluated by cox regression analysis.

Results: The expression of EBP1 was lower compared with adjacent normal tissues (p=0.01). EBP1 expression was significantly correlated with larger tumour size (p=0.03), metastasis (p=0.04), and advanced clinical stage (p=0.01). Univariate analysis of OS revealed that the relative level of EBP1 expression (p=0.002), tumor size (p=0.05), metastasis (p=0.04), and clinical stage (p=0.001) were prognostic indicators. Furthermore, multivariate analysis revealed that clinical stage (p=0.01) and EBP1 expression (p=0.03) were independent prognostic indicator for OS in HCC.

Conclusions: In conclusion, this study suggested that EBP1 expression was an independent prognostic indicator for OS in HCC.

Author(s): Min-Lan Hu, Yan Qin, Xiao-Yan Wang

Abstract Full Text PDF