- Asian Journal of Biomedical and Pharmaceutical Sciences (2014) Volume 4, Issue 35
Role of Embelin on Lithium Induced Nephrogenic Diabetes Insipidus in Albino Rats
Objective - The aim of this study was to investigate nephroproprotective effect of Embelin in lithium induced nephrogenic diabetic inspidus.
Method – Nephrogenic diabetes insipidus were induced in rats by injection of Lithium (4meq/kg/day or 27.76mg/kg/day I.P.), dissolved in normal saline for 6 day .Animals with profound polyuria daily urinary output 50-70% of the body weight were selected for study.daily urine output was assessed for confirmation of NDI.
Result – The result of this study that embelin show nephroprotective effect by lower plasma creatinine urinecreatinine ,urine sodium, potassium, magnesium, & nitric oxide level of kidney and also increase glutathione level of kidney
Conclusion – The renoprtective effect action of embelin due to free radical scavenging effect & vasodilatory action. Thus embelin prevent lithium induced oxidative stress and renal ischemia.