Biomedical Research

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Rational analysis of adverse drug reactions cases in Northland of China

Objective: To learn about ADRs of antibacterial drugs in our Hospital and to provide references for rational drug use.

Methods: Conduct retrospective studies, classification statistics, analysis and assessment on 469 ADR reports of antibacterial drugs collected between January 2015 and December 2016 in the hospital. Register ADR’s names, levels, results, drugs’ names, routes of administration, patients’ ages, gender, and his/her original disease.

Results: 45 kinds of drugs were involved among the 469 ADR reports, with a larger proportion of drugs for children (29.54%); the major route of administration was intravenous (73.26%); lesion of skin and its appendages were main clinical manifestations (61.35%), which was 25.00% of the total number; Levofloxacin and Azithromycin have ADR incident rates.

Conclusion: Causes for ADRs of antibacterial drugs are complex, so medical workers should enhance the supervision over the antibacterial drugs, deepen their understanding of ADRs, and take necessary interventions to reduce or avoid the occurrence of ADRs as much as possible.

Author(s): Huili Wang, Yunxia Li, Jing Wu