Odontogenic myxomas are rare benign mesenchymal tumours of head and neck with a potential for local infiltration and recurrence. They appear to originate from the dental papilla, follicle or periodontal ligament in mandible and less commonly the maxilla. These usually present in second or third decade of life as slowly progressive space occupying lesion in the jaw giving a mixed radiopaque-radiolucent appearance. The treatment is considered to be wide local excision in view of high recurrence with curettage alone. Here, we present a case of odontogenic myxoma of maxilla, in a 40 year old lady, with a brief review of literature, clinical, radiological, histopathological characteristics and therapeutic modality employed.