Biomedical Research

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Observation of the short- and long-term effects of parametrial implant radiotherapy technique in treating patients with mid- and late-stage cervical cancer

Purpose: To explore and discuss the short- and long-term effects of parametrial implant radiotherapy technique on cervical cancer treatment.

Methods: The study recruited 124 subjects from the Department of Radiotherapy of the hospital where the author is employed. The subjects were patients with mid- and late-stage localized cervical cancer who received treatment from October 2011 to May 2016. Patients were classified into the treatment and control groups. Each group comprised 62 subjects. The same synchronous sensitization chemotherapy regimen was observed for all subjects. Patients in the control group received pelvic cavity external irradiation and single after-loading intracavitary brachytherapy, whereas patients in the treatment group received parametrial implants combined with after-loading intracavitary brachytherapy. Tumor shrinkage, negative side effects of treatment, and one-, three-, and five-year survival rates were observed.

Results: The recent effective rate of therapy for the treatment group was 100.0% and higher than that of the control group (96.8%). The difference in effective rates between the two groups was statistically significant (P<0.05). The treatment group had higher one-, three-, and five-year survival rates than the control group. The difference in survival rates between the two groups was statistically significant (P<0.05). The patients in the treatment group who survived for one, three, and five years were 22.6%, 41.9%, and 35.5%, respectively. The patients in the control group who survived for one, three, and five years were 16.1%, 38.7%, and 45.2%, respectively. The rectitis incidence rates of patients in the treatment group who survived for one, three, and five years were 32.2%, 46.8%, and 21.0%, respectively. The rectitis incidence rates of patients in the control group who survived for one, three, and five years were 25.8%, 40.3%, and 33.9%, respectively. The incidence of untoward effects was not statistically significant (P>0.05).

Conclusion: Parametrial implant radiotherapy technique effectively treats mid- and late-stage cervical cancer without causing new untoward effects. Therefore, the further promotion and application of parametrial implant radiotherapy technique are encouraged.

Author(s): Zhao-Liang Chen, Hong Liu, Hui-Li Yang, Yu-Kai Gao, Gong-Wen Zhang