Cerebral ischemia may be due to primary thrombosis in carotid artery. This results in cerebral hypoxia and thus leading to cerebral infarction/ischemic stroke. The effect of CGE (C. glandulosum extract) on antioxidant status in I/R (ischemia-reperfusion) injury in the rat forebrain have been investigated. Further, its effect was assessed on behavioural parameters, infract size and histopathological parameters. Bilateral carotid artery occlusion followed by reperfusion produced significant cerebral infarction and impaired short term memory, motor co-ordination and lateral push response CGE markedly attenuated I/R induced cerebral injury in terms of decreased infarct, size. The result suggests that the use of CGE protect ischemia reperfusion induced cerebral injury with comparable potency.