Case Report - Gynecology and Reproductive Endocrinology (2018) Volume 2, Issue 2
Lutheal phase stimulation and fertility and first outcomes.
During the menstrual cycle, ovarian follicles show dynamic morphologic and endocrine changes.
Traditionally, folliculogenesis has been described to begin at the luteal phase with follicular
recruitment, afterwards during the early follicular phase; a dominant follicle is selected while the
rest undergo atresia. However, recent studies suggest that small antral follicles remain during the
luteal phase, which do not undergo atresia and thus, are still capable of ovulating and can even
result in pregnancy. These findings offer new possibilities for ovarian stimulation in selected cases.
Ovarian stimulation not started at the early follicular phase, (unconventional stimulation), may
offer advantages against traditional protocols, such as flexibility to initiate stimulation at any given
moment during the menstrual cycle. Suitable for oncology patients aiming to preserve fertility
and a higher yield of oocytes retrieved per started cycle, which could be particularly attractive in
patients with an initial poor ovarian response.
The efficacy of the luteal phase stimulation protocols is promising compared to single-stimulation
protocols. To our knowledge, we report the first series of cases of unconventional stimulation (luteal
phase) in Mexico and Latin America. Author(s): Luis M Campos Olmedo, Miguel de J LÃÂ³pez Rioja, Cristina M SÃÂ¡nchez GonzÃÂ¡lez, Paula N Zavala GonzÃÂ¡lez,
Yesenia Recio LÃÂ³pez, Alejandro Chavez Badiola
Abstract Full Text PDF