Biomedical Research

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In-vitro cytotoxicity of biosynthesized Zinc oxide nanoparticles towards cardiac cell lines of Catla catla

Objective: The present report describes the green synthesis of Zinc oxide nanoparticles (ZnO NPs) using Argemone maxicana leaf extract by an eco-friendly approach. Also, the in-vitro cytotoxicity of prepared ZnO NPs against the cardiac cell lines of Sahul India Catla catla fish (SICH) was studied.

Methods: ZnO NPs were prepared by using Argemone maxicana leaf extract as reducing and stabilizing agent. The synthesized ZnO NPs have been characterized by using techniques such as FT-IR, XRD, UVVis, Photo luminescence, EDS and SEM instruments. Also, the in-vitro cytotoxicity of the synthesized ZnO NPs was tested against the SICH cell lines.

Results: The synthesized ZnO NPs were analysed using different characterization techniques. XRD and SEM have confirmed the cubic structure of the prepared ZnO NPs with crystalline nature. FTIR showed the capping of plant biomolecules onto the surface of ZnO NPs. The in-vitro cytotoxicity of Argemone maxicana extract mediated ZnO NPs showed the concentration dependant cytotoxicity against SICH cell lines.

Conclusions: A simple, fast and environment friendly approach for the preparation of ZnO NPs using Argemone maxicana leaf extract is showed in this work. Argemone maxicana extract mediated ZnO NPs have showed the concentration dependant cytotoxicity against SICH cell lines.

Author(s): Wei Ji, Diqi Zhu, Yiwei Chen, Jingjing Hu, Fen Li