Non-aqueous system are well known as solvent or drug suspension vehicles and oleogels micro emulsion with no aqueous phase (anhydrous, non-aqueous oil-in-oil emulsion) have had relatively scant attention yet may have uses as drug reservoir as well as template for the preparation of microemulsion combination with a cosurfactant. Microemulsions have emerged as novel vehicles for drug delivery which allow sustained or controlled release for percutaneous, oral, topical, transdermal, ocular and parenteral administration of medicaments. They offer the advantage of spontaneous formation, ease of manufacturing and scale-up, thermodynamic stability, improved drug solubilization of hydrophobic drugs and bioavailability. Delivery of drug using theses microemulsion through skin increase the local systemic delivery of the dug by different mechanism that make them suitable vehicles for the delivery of antifungal agent. Novel anhydrous micro emulsions, which may offer some advantages as depot or reservoir vehicles for lipophilic drugs in controlled delivery systems, intramuscular absorption.