Biomedical Research

- Biomedical Research (2010) Volume 21, Issue 4

Increased level of Lipid peroxidation in preeclamptic pregnancy; a rela-tionship with paraoxanase 1(PON1) activity

The aim of the study was to evaluate the status and diagnostic utility of PON1as indicator of antioxidant status in preeclampsia. Study groups involved cases, women with preeclampsia (BP >140/90mmHg, edema and proteinuria) (n=30) and controls, pregnant women without preeclampsia or any other complications attending hospital for antenatal checkup (n=30). Both cases and control groups were not on any vitamin E/ vitamin C supplementation. Fast-ing venous samples of blood were collected from both cases and controls. Serum PON1 and serum malondialdehyde (MDA) levels were measured spectrophotometrically. Students in-dependent‘t’ test and Pearsons correlation were used for statistical analysis. We found that PON1 activity in preeclampsia cases were significantly lower than in normal pregnancy con-trols while MDA levels were significantly higher. Conclusion: Our Study showed that the in-crease in Oxidative stress in preeclampsia cases is associated with a decrease in PON1 anti-oxidant activity.

Author(s): KS Meera, S Maitra, R Hemalatha

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