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In vitro effectiveness of linezolid in brucellosis

Antibiotic sensitivities for Linezolid of 20 strains that reported as Brucella melitensis in blood cultures between 2014 and 2016 were evaluated by disc diffusion and E-test methods. According to the disc diffusion method results, 20 Brucella melitensis strains had ≥ 25 mm of antibiotic sensitivity zones. Etest measurements revealed that MIC values were between 1.5 and 6 μg. Linezolid can be an alternative when the treatment of Brucellosis prolongs and becomes difficult due to recurrences and relapses, or when it becomes complicated in cases like spondylodiscitis or neurobrucellosis.

Author(s): Hakan Sezgin Sayiner, Sadik Akgun