Biomedical Research

- Biomedical Research (2007) Volume 18, Issue 2

Glutathione and related enzymes in Parkinson's Disease

In the present study 25 patients of Parkinson disease (PD) under treatment, between 40-80 years, of both sexes with the written informed consent were selected and compared with age and sex matched 25 healthy individuals as controls. An attempt was made to study the role of blood reduced glutathione (GSH), Glutathione-S- transferase (GST) and γ-Glutamyl transpeptidase (GGT) in PD. The results showed a decrease in GSH (p<0.01) and GST (p<0.05) with an increase in GGT (p<0.01), according to students unpaired ‘T’ test, which may be a reflection of changes in the substantia nigra associated with PD.

Author(s): Jyothi d'souza, Beena V Shetty, Sudha K, Gayathri M Rao

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