Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article - Biomedical Research (2018) Volume 29, Issue 6

Effect of serum Th1/Th2 cytokine imbalance on the occurrence and development of various chronic glomerulonephritis

Objective: To explore the changes of serum interferon-γ (IFN-γ) and interleukin-10 (IL-10) of various chronic glomerulonephritis (CGN) patients and further investigate the effect of serum cytokine Th1/Th2 on the occurrence and development of various CGN.

Methods: Venous blood of 9 patients with IgA mesangioproliferative glomerulonephritis (IgA nephropathy), 18 patients with non-IgA mesangioproliferative glomerulonephritis (non-IgA MsPGN), 7 patients with membranous nephropathy (MN), 6 patients with focal segmental sclerosing glomerulonephritis (FSGS), 14 patients with chronic renal failure, and 20 health people were collected for the study. Serum IFN-γ and IL-10 were assayed by double antibody sandwich ELISA, and there was a measurement of 24 h urinary protein excretion and serum creatinine which were statistically analysed.

Results: The IFN-γ of the patients with IgA nephropathy or non-IgA MsPGN saw a great growth, but that of the patients with MN badly reduced, and IFN-γ of the patients’ non-IgA MsPGN was positively related to 24 h urinary protein excretion; IL-10 of the patients IgA nephropathy, non-IgA MsPGN, FSGC and CRF saw a significant decrease, and that of the patients with CRF was negatively associated with serum creatinine.

Conclusion: Serum IFN-γ plays a role in the improvement of immunologic injury of mesangioproliferative glomerulonephritis which is related to the formation of proteinuria; the occurrence and development of CGN is closely linked to the decrease of IL-10, so does the development of CRF, and the imbalance of serum TH1/TH2 cytokines has certain correlation with clinical indexes.

Author(s): Li Xiaoli, Xu Pengcheng

Abstract Full Text PDF