Biomedical Research

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Effect of Gastrodia elata-notoginseng decoction on blood pressure variability and inflammatory factors in old hypertensive patients with yin-deficiency and yang-hyperactivity syndrome

Objective: This research was aimed to explore the decoction ability of Gastrodia elata-notoginseng of blood pressure variability and inflammatory factors in old hypertensive patients with yin-deficiency and yang-hyperactivity syndrome.

Methods: Totally 80 hypertensive patients with yin-deficiency and yang-hyperactivity syndrome were randomly divided into control group (40 cases) and treatment group (40 cases). Two groups received Lamlodipine 2.5 mg q.d., one tablet daily), and the treatment group additionally received Gastrodia elatanotoginseng decoction. Both groups were continuously treated for 12 weeks.

Results: The treatment efficacy in treatment group (85.0%) was higher than control group (62.5%) and the difference was statistically significant (P<0.01). After treatment, various parameters of treatment group were significantly lower (P<0.01 or P<0.05) than that of control group, including 24 h systolic pressure standard deviation (24 h SSD), 24 h diastolic pressure standard deviation (24 h DSD), diurnal systolic pressure Standard Deviation (dSSD), nocturnal systolic pressure standard deviation (nSSD), 24 h mean systolic blood pressure (24 h SBP), serum resistin level, C-reactive protein (CRP) level and adiponectin level.

Conclusions: Compared with Western medicine therapy only, Gastrodia elata-notoginseng decoction can further decrease blood pressure.

Author(s): Wang Dengqin, Zhang Xiaoxue, Song Guohong, Li Lei, Sun Bing