Systemic Lupus Erythematous (SLE) is a chronic autoimmune disease that can involve any organ system, and may lead to significant morbidity and even mortality. In this article we review the epidemiology, common clinical features, complications of disease, and address the new available treatment idea. Further, we discuss important affection of the disease medically on children. Review methods: The study was done on a patient with systemic lupus here age is 16 years old came to us with common clinical manifestation of the disease, here kidney and liver lab's value was abnormal and some skin symptoms was found so we start to restrict some types of food by taking general diet advices and start to look at the effect of diet therapy on the disease prognosis. Conclusion: Noticed an improvement in both kidney and liver profile and disappearing of the butterfly rash, also here general blood test has improved including anemia, lymphocytes, liver enzymes, total protein in urine, C-Reactive protein, also their IGG value was reduced to normal level after their elevation.