Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Research Article - Biomedical Research (2019) Volume 30, Issue 6

Diosmin anti-tumor efficacy against hepatocellular carcinoma

Background: Cancer is a life threatening deadly disease considered as a major health concern globally. Hepatocellular Carcinoma (HCC) is a foremost health anxiety in developing and developed nations due to a variety of etiologies factors, including Hepatitis virus, superfluous storage of iron in the body, exposure to toxins and carcinogens which directly affect the cellular mechanism. Objective: The present investigation involved in analyzing anti-cancer potential of diosmin through in vitro and in vivo examination. Materials and methods: The present study absorbed the anti-cancer activity of diosmin at 50, 100, 150, 200 μM/ml for 24 hours of treatment on dose dependent manner. Group II animals were administrated 0.01% NDEA to induce primary liver carcinoma. Cancer bearing experimental animals were treated orally with the drug diosmin at the dosage level of 200 mg per kg/body weight for 28 successive days. Results: Diosmin treatment on HepG2 cells constrains nearly half of the cell population and proliferation at the dose of 100 μM/ml and in vivo experimental studies showed remarkable repossession in biochemical and morphological characteristics. Conclusion: These results summarizes that both in vivo and in vitro anti-carcinogenic activity of diosmin could be an outstanding flavonoid in the treatment of HCC because of its therapeutic and pharmacological properties.

Author(s): Perumal S, Langeswaran K

Abstract PDF

Get the App