Biomedical Research

Journal Banner

Clinical efficacy of laparoscopic minimally invasive surgery for rectal cancer and its effect on anorectal dynamics

Objective: The aim of this work is to investigate the clinical efficacy of laparoscopic minimally invasive surgery for rectal cancer and its effect on anorectal dynamics.

Methods: A total of 150 patients with rectal cancer who were admitted in our hospital from January 2015 to January 2017 were selected. The patients were divided into A group (n=80) and B group (n=70) according to the treatment method administered to them. The patients in the A group underwent minimally invasive laparoscopic surgery, whereas the patients in B group underwent laparotomy. The clinical efficacies and effects on anorectal dynamics between the two groups were compared.

Results: The operation duration of the A group (211.41 ± 17.67 min) was significantly longer than that of B group (p<0.05). The intraoperative blood loss (101.16 ± 15.24 ml), exhaust time (45.69 ± 11.53 min), and time of off-bed (42.32 ± 12.78 h) were significantly lower than those of the B group (p<0.05). The length of anal high pressure zone, anal resting pressure, and anal maximal systolic pressure of the A group at first, second, and fourth postoperative months were significantly higher than those of the B group (p<0.05). In the same periods, the MTL (168.61 ± 12.32, 180.65 ± 12.68, and 203.72 ± 13.63 pg/ml, respectively), GAS (76.73 ± 4.31, 81.84 ± 5.28, and 91.43 ± 5.75 μmoL/L, respectively), and NPY (156.64 ± 9.36, 165.37 ± 10.43, and 181.86 ± 11.53 pg/ml, respectively) of the A group were significantly higher than those of the B group (p<0.05).

Conclusion: Minimally invasive laparoscopic surgery for rectal cancer offer short operation time, decreased intraoperative blood loss, and minimal trauma to the body and effects on anorectal dynamics and gastrointestinal hormones, which are beneficial to the postoperative rehabilitation of patients.

Author(s): Binbin Du, Weisheng Zhang, Xiongfei Yang, Dewang Wu, Yaochun Lv, Tao Wang