Solanum nigrum Linn. is used in Indian traditional and folklore medicines to cure various ailments. Crude extracts of different plant parts of S. nigrum were obtained using different solvents viz. petroleum ether, chloroform, acetone, ethanol and methanol. Phytochemical constituents in different solvent extracts were analyzed. In vitro antibacterial studies on the leaf extracts were carried out on selected bacterial strains Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, Klebsiella pneumonia, using disc diffusion assay. Results indicate that the leaf aqueous extract was more active against all the microbes tested however, with variations. This indicates that the composition of phytochemicals depend on the type of solvent system employed in extraction.