Biomedical Research

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Association of IL-18 genetic polymorphisms and haplotypes with breast cancer risk in a Chinese population

Objective: We performed a case-control study to evaluate the role of IL-18-07C/A (rs1946518) and -137G/C (rs187238) polymorphisms in the development of breast cancer.

Methods: A total of 305 breast cancer patients and 305 healthy controls were recruited between May 2015 and May 2016. The genotyping of IL-18 -607C/A and -137G/C polymorphisms was carried out by an iPlex GOLD SNP genotyping analysis using the Sequenom MassARRAY® System.

Results: We observed that the CC genotype of IL-18 -607C/A was associated with breast cancer risk (OR=1.80, 95%CI=1.06-3.07), when compared with the CC+CA genotype. The CC genotype of IL-18 -137G/C had a 2.90 fold risk of breast cancer as compared to the CC genotype, and the CC genotype also showed an increased risk of breast cancer compared with the GG+GC genotype (OR=2.94, 95%CI=1.41-6.11). A completely linkage disequibrium was found between IL-18 rs1946518 and rs187238 (D’=1.00, r2=0.19). The A-C (OR=1.52, 95%CI=1.11-2.08) and C-G (OR=0.79, 95%CI=0.62-0.99) haplotypes were associated with breast cancer risk.

Conclusion: We found that IL-18 -607C/A and -137G/C polymorphisms and haplotypes contribute to increase the breast cancer risk.

Author(s): Yue Zhao, Shuai Wang, Zhenchao Zhang, Chuan Qin, Xianjun Yang, Qing Xie