Asian Journal of Biomedical and Pharmaceutical Sciences

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Assessment of Histologic Features of Different Tissues of Female Wistar Rats Dosed with Counterfeit Neurobion®

Tissue histology results still remain one of important tools used to assess the harmful effects of a xenobiotic on many organs in the field of Toxicology. Exposure to fake drug is a common occurrence in a Third World country like Nigeria. The impact of fake neurobion on tissues such brain, lung, heart and ileum is therefore being investigated. Adult female albino rats employed for the study were randomly divided into 3 groups of 6 rats per group. Rats in group 1 were treated with 30 mg/kg of fake neurobion, group 2 rats were administered with 30 mg/kg BW of genuine neurobion®, while rats in group 3 (control) received distilled water. Determination of the possible harmful effects of this agent on tissues was probed using haematoxylin and eosin (H & E) technique. The results of the study did not reveal any alteration in the histologic manifestations of all the tissues examined, as all featured no visible lesions. While these results suggest that the formulation is not toxic to cells of the brain, heart, lung and ileum it does not preclude a possible alteration of the micronutrients. It is therefore being suggested that serum micronutrients levels of rats treated with this fake neurobion be investigated.

Author(s): Iyanda AA, Oparinde DP, Iheakanwa CI