Atrial fibrillation stands as one of the most common supraventricular arrhythmias. Its incidence in general population has escalated significantly over the last few decades. The health-related quality of life (HRQoL) of patients with atrial fibrillation is currently a vital concern in cardiovascular health management. Accordingly, key elements of meager HRQoL of AF patients demand better clarification. Nowadays, several reports have tested the mutual relation between anxiety and AF initiation and progression. Significantly, anxiety affects how the patients approach their disease and, additionally, anxiety may affect the efficiency of various AF therapies. The goal of this research is to explore an area that considered by patients to be challenging before the therapeutic work-up. Study concluded that there is a multifaceted relationship between AF and anxiety. AF can ground anxiety among patients and equally, anxiety can pave a background that is favorable for the initiation and Progression of AF.