Objective: A pharmacological study to explore Anti stress Potential of Simvastatins in stress produced models of mice.
Method and Materials: Either sex of Wistar rats were used for studying the activity of statins (simvastatin) in stress condition and their activity in brain. Animals were divided into five groups and each groups having six animals. Freshly prepared alloxan (80 mg/kg) i.p. were given to fourth and fifth group to produced oxidative stress. first group received normal saline, second group received standard drug Piracetum (500 mg/kg) orally, third group received test drug simvastatin (50 mg/kg) orally and also fifth group received simvastatin (50 mg/kg) orally after treatment with alloxan (80 mg/kg.) and by using certain test like Marble burying and coock’s pole climbing we find out the effect of our drugs in different groups of animals.
Result: With the help of investigation of biochemical parameters of different groups of animals we found out that simvavastatin showed significantly lowering the oxidative stress and enhancing the memory of rats. Evaluation of group second (standard group) were approximately same as groups third (treated by simvavastatin). And group fifth suppressed the oxidative stress induced by the alloxan.
Conclusion: Simvastatin significantly suppressed the oxidative stress and helpful in enhancing the memory.